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Title of Journal: Arch Pharm Res

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Abbravation: Archives of Pharmacal Research

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Pharmaceutical Society of Korea

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DOI

10.1002/zaac.19905900102

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1976-3786

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Formulation and biopharmaceutical evaluation of a

Authors: YunSeok Rhee Thuong Nguyen EunSeok Park SangCheol Chi
Publish Date: 2013/03/11
Volume: 36, Issue: 5, Pages: 602-607
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Abstract

To reduce the adverse effects of aceclofenac that accompanied with oral administration of this drug transdermal patches in the form of druginadhesive DIA patches containing aceclofenac were formulated The effect of formulation factors on the skin permeation of the drug and physical properties of the patch were evaluated using excised rat skins The optimized patch contained 12  aceclofenac and 20  lauryl alcohol in DT2852 as a pressuresensitive adhesive The pharmacokinetic characteristics of the DIA patch were determined after application of the transdermal patches to human volunteers The calculated relative bioavailability of the aceclofenac DIA patch was 182  compared to oral administration of the drug The findings of this study suggest that transdermal application of aceclofenac can substitute for oral administration of the drug

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