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Title of Journal: Arch Pharm Res

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Abbravation: Archives of Pharmacal Research

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Pharmaceutical Society of Korea

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DOI

10.1006/jabr.1996.0232

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1976-3786

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Comparison of two Emphasis Type="Italic"Candida

Authors: Yongmoon Han Ki Yon Rhew
Publish Date: 2012/12/04
Volume: 35, Issue: 11, Pages: 2021-2027
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Abstract

We have previously shown that Candida albicans mannan extract encapsulated in liposomes Lipomann or conjugated to a protein bovine serum albumin Conjumann induces the production of antibody in BALB/c mice with normal complement system that protect against disseminated candidiasis In this present study we determined the protective abilities of two formulae in a C5deficient mouse model of disseminated candidiasis It is known that the lack of C5 is known to aggravate candidal infection In experiments BALB/c or C5deficient miceDBA/2J and AKR mice were immunized with one of the formulae before intravenous challenge with live C albicans yeast cells and their degrees of survivability were measured Results showed that Conjumann was 100 protective in BALB/c mice against disseminated candidiasis whereas only 60 of Lipomann immunized mice survived the entire 50 day observation period p 005 With the DBA/2J strain Conjumann resulted in a partial protection but Lipomann had no protection The conjugate vaccine enhanced the resistance of AKR mice which resulted in three survivors of the five Conjuimmunized AKR mice until the end of 50 day observation period p 005 Lipomann showed little protection in AKR mice By agglutination analyses it was determined that there was the same level of production of polyclonal antisera specific to the mannan regardless of the mouse strains All data indicate that both formulations require complement in the protection However Conjumann appears to be superior to Lipomann because the conjugate vaccine is protective even in the absence of C5 These observations suggest that the conjugate vaccine can be an excellent vaccine formulation against C alibicans infections

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