Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Arch Pharm Res

Search In Journal Title:

Abbravation: Archives of Pharmacal Research

Search In Journal Abbravation:

Publisher

Pharmaceutical Society of Korea

Search In Publisher:

DOI

10.1007/bf00604905

Search In DOI:

ISSN

1976-3786

Search In ISSN:
Search In Title Of Papers:

A new naphthalene glycoside from Emphasis Type="I

Authors: Byongkyu Shin Jinhee Kim Ki Sung Kang HuiShan Piao Jeong Hill Park Gwi Seo Hwang
Publish Date: 2015/04/11
Volume: 38, Issue: 11, Pages: 2059-2065
PDF Link

Abstract

A new naphthalene glycoside was isolated from the leaves and stems of Chimaphila umbellata Barton Its chemical structure was elucidated to be 27dimethyl14dihydroxynaphthalene1Oβdglucopyranoside DMDHNG based on spectroscopic evidence DMDHNG significantly inhibited the receptor activator of nuclear factorκB ligand RANKLinduced tartrateresistant acid phosphatase TRAP activity and the formation of multinucleated osteoclasts in a dosedependent manner In addition the new glycoside inhibited the RANKLinduced mRNA expression of osteoclastassociated genes that encode TRAP cathepsin K and another transcription factor—nuclear factor of activated Tcells c1 We believe that the inhibitory effects of DMDHNG on the osteoclast differentiation may be exploited for a therapeutic benefitThis work was supported by the BioSynergy Research Project NRF2012M3A9C4048796 of the Ministry of Science ICT and Future Planning through the National Research Foundation The authors wish to acknowledge the financial support of Gachon University Research Fund

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Formulation and biopharmaceutical evaluation of a transdermal patch containing aceclofenac
  2. Causal effects of synthetic chemicals on mitochondrial deficits and diabetes pandemic
  3. Synthesis and biological evaluation of novel fluconazole analogues bearing 1,3,4-oxadiazole moiety as potent antifungal agents
  4. Inhibitory activities of the alkaloids from Coptidis Rhizoma against aldose reductase
  5. New anti-inflammatory thiazolyl-carbonyl-thiosemicarbazides and thiazolyl-azoles with antioxidant properties as potential iNOS inhibitors
  6. Pharmacokinetics of verproside after intravenous and oral administration in rats
  7. Ginsenoside Rc modulates Akt/FoxO1 pathways and suppresses oxidative stress
  8. A new stilbene glucoside gallate from the roots of Polygonum multiflorum
  9. Anti-inflammatory and anti-nociceptive activities of compounds from Tinospora sagittata (Oliv.) Gagnep.
  10. Prostaglandin E 2 -mediated dysregulation of proinflammatory cytokine production in pristane-induced lupus mice
  11. Lipoxygenase inhibitors from the latex of Calotropis Procera
  12. Inhibition of DNA topoisomerases I and II of compounds from Reynoutria japonica
  13. Developing Streptomyces venezuelae as a cell factory for the production of small molecules used in drug discovery
  14. The relevance of polymeric synthetic membranes in topical formulation assessment and drug diffusion study
  15. Synthesis of 2-alkynyl substituted 4′-thioadenosine derivatives and their binding affinities at the adenosine receptors
  16. Evaluation of skin permeation and accumulation profiles of a highly lipophilic fatty ester
  17. Modulation of the genomic estrogen receptor pathway by water extracts of Cirsium japonicum
  18. Modulation of the genomic estrogen receptor pathway by water extracts of Cirsium japonicum
  19. In vivo electron spin resonance: An effective new tool for reactive oxygen species/reactive nitrogen species measurement
  20. Optimization of ultrasonic-assisted extraction of continentalic acid from the root of Aralia continentalis by using the response surface methodology
  21. Anti-inflammatory properties of samidin from Seseli resinosum through suppression of NF-κB and AP-1-mediated-genes in LPS-stimulated RAW 264.7 cells
  22. Alloxan-induced diabetic thermal hyperalgesia, prophylaxis and phytotherapeutic effects of Rheum ribes L. in mouse model
  23. Cytoprotective roles of senescence marker protein 30 against intracellular calcium elevation and oxidative stress
  24. Analysis of the inhibitory activity of Abeliophyllum distichum leaf constituents against aldose reductase by using high-speed counter current chromatography
  25. Bioassay-guided isolation of fatty acid synthase inhibitory diterpenoids from the roots of Salvia miltiorrhiza Bunge
  26. Synthesis, characterization and biological activity of a series of carboxamide derivatives of ofloxacin
  27. The intracellular uptake ability of chitosan-coated Poly (D,L-lactideco-glycolide) nanoparticles
  28. Inhibitory effect of homochlorcyclizine on melanogenesis in α-melanocyte stimulating hormone-stimulated mouse B16 melanoma cells
  29. Carboxymethyl flavonoids and a monoterpene glucoside from Selaginella moellendorffii
  30. The effective mechanism of the polysaccharides from Panax ginseng on chronic fatigue syndrome
  31. Anti-hyperalgesic and anti-inflammatory effects of Ketorolac Tromethamine gel using pulsed ultrasound in inflamed rats
  32. Comparison of two Candida mannan vaccines: The role of complement in protection against disseminated candidiasis
  33. Antioxidant activity of 3,4,5-trihydroxyphenylacetamide derivatives
  34. Effect of sodium carboxymethylcellulose and fucidic acid on the gel characterization of polyvinylalcohol-based wound dressing
  35. Rhein lysinate inhibits monocyte adhesion to human umbilical vein endothelial cells by blocking p38 signaling pathway
  36. Phenolic compounds with IL-6 inhibitory activity from Aster yomena
  37. Dose-independent pharmacokinetics of a new peroxisome proliferator-activated receptor-γ agonist, KR-62980, in Sprague-Dawley rats and ICR mice
  38. Aloin protects against chronic alcoholic liver injury via attenuating lipid accumulation, oxidative stress and inflammation in mice
Search Result: