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Title of Journal: Arch Pharm Res

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Abbravation: Archives of Pharmacal Research

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Publisher

Pharmaceutical Society of Korea

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DOI

10.1007/bfb0085121

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ISSN

1976-3786

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Synthesis of 2alkynyl substituted 4′thioadenosin

Authors: ChengWu Liang Won Jun Choi Lak Shin Jeong
Publish Date: 2008/09/12
Volume: 31, Issue: 8, Pages: 973-
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Abstract

On the basis of high binding affinity of 2hexynylN 6methyladenosine and N 6substituted4′thioadenosine derivatives at the A3 adenosine receptor AR novel 2alkynylsubstitutedN 6methyl4′thioadenosine derivatives combining the characteristics of two classes of nucleosides were designed and synthesized from Dgulonic γlactone via palladiumcatalyzed cross coupling reaction as a key step Among compounds tested only compound 3b showed moderate binding affinity at the human A3 adenosine receptor without binding affinities at other subtypes

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