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Title of Journal: Arch Pharm Res

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Abbravation: Archives of Pharmacal Research

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Pharmaceutical Society of Korea

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DOI

10.1007/s10734-010-9319-5

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1976-3786

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Modulation of the genomic estrogen receptor pathwa

Authors: MiKyung Park Meera Rhyu ByungKoo Yoon Hyeok yi Kwon Siyoul Jang Young Joo Lee
Publish Date: 2008/03/14
Volume: 31, Issue: 2, Pages: 225-230
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Abstract

We investigated the estrogenic activity of Cirsium japonicum water extracts which have long been used to treat vascularrelated diseases The activity of the extracts was characterized in a transient transfection system using estrogen receptor isoforms and estrogenresponsive luciferase plasmids in HEK 293 cells The extract activated both and estrogen receptors Activation was inhibited by the estrogen receptor antagonist ICI 182780 indicating that the effects were mediated through the estrogen receptor isoforms Treatment with the extracts increased expression of the progesterone receptor and pS2 genes and expression of estrogen receptor was decreased in MCF7 cells These results suggested that the Cirsium japonicum water extracts showed estrogenic effects and may be a potential clinical application for treatment of estrogen related vascular diseases

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