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Title of Journal: Arch Pharm Res

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Abbravation: Archives of Pharmacal Research

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Pharmaceutical Society of Korea

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DOI

10.1007/bf00291460

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ISSN

1976-3786

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Cytoprotective roles of senescence marker protein

Authors: Tae Gen Son So Jung Kim Keunho Kim MinSun Kim Hae Young Chung Jaewon Lee
Publish Date: 2008/08/14
Volume: 31, Issue: 7, Pages: 872-877
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Abstract

Senescence marker protein 30 SMP30 is identified as an important aging marker molecule and known to play multifunctional roles as an intracellular calcium regulatory protein in the signaling process To elucidate the functional significance of SMP30 we established the stably transfected P19 cell line with SMP30 expression vector Overexpression of SMP30 slightly suppressed the proliferation of P19 cells However SMP30 overexpression was cytoprotective against calciummediated stress such as calcium ionophore A23187 and thapsigargin We found that SMP30 overexpression reduced the elevated intracellular calcium levels induced by A23187 but not by thapsigargin In addition SMP30 transfected P19 cells were more protective to tertbutylhydroperoxide induced cytotoxicity indicating the antioxidative properties of SMP30 Taken together our results suggest that external calcium regulation and antioxidant properties are involved in the cytoprotective mechanism of SMP30

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