Authors: Eun Jeong Park Hyun Sook Lee SeiRyang Oh HyeongKyu Lee Hye Suk Lee
Publish Date: 2009/04/29
Volume: 32, Issue: 4, Pages: 559-
Abstract
Verproside a catalpol derivative iridoid glucoside isolated from Pseudolysimachion longifolium is a candidate for antiasthmatic drug The dosedependency of the pharmacokinetics of verproside was evaluated in rats after intravenous and oral administration After intravenous administration of verproside 2 5 and 10 mg/kg doses the systemic clearance Cl was significantly reduced and AUC was significantly increased at 10 mg/kg dose compared to 2 and 5 mg/kg doses The volume of distribution at steady state V ss remained unchanged as the dose was increased The extent of urinary excretion was low for both intravenous 33–62 and oral 001–004 doses Isovanilloylcatalpol was identified as a metabolite after intravenous administration of verproside and showed the significant decreases in AUC and C max at 10 mg/kg verproside dose The reduced systemic clearance of verproside at high doses appears to be due to the saturable metabolism Upon oral administration of verproside 20 50 and 100 mg/kg doses C max was nonlinearly increased The extent of verproside recovered from the gastrointestinal tract at 24 h after oral administration was 001–072 for all three doses studied The absolute oral bioavailability F was 03 and 05 for 50 and 100 mg/kg doses respectively Low F appears to be due to firstpass metabolism
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