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Title of Journal: Arch Pharm Res

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Abbravation: Archives of Pharmacal Research

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Pharmaceutical Society of Korea

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DOI

10.1007/s11764-011-0178-6

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1976-3786

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Inhibition of DNA topoisomerases I and II of compo

Authors: Kyoung Hwangbo Ming Shan Zheng YoungJin Kim JongYeop Im ChongSoon Lee MiHee Woo Yurngdong Jahng HyunWook Chang JongKeun Son
Publish Date: 2012/10/09
Volume: 35, Issue: 9, Pages: 1583-1589
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Abstract

Three anthraquinones 1 2 and 4 three stilbenes 5 6 and 7 and 35dihydroxybenzyl alcohol 3 were isolated from Reynoutria japonica Their structures were identified as emodin 1 emodin8Oβdglucoside 2 35dihydroxybenzyl alcohol 3 citreorosein 4 cisresveratrol 5 transresveratrol 6 and transresveratrol5Oβdglucopyranoside 7 by comparing their physicochemical and spectral data with published data Compound 3 was isolated for the first time from the Polygonaceae family Among the purified compounds 3 showed more potent inhibitory activity against topoisomerase I IC50 4 μM than camptothecin as the positive control IC50 18 μM Compounds 3 4 5 6 and 7 showed stronger inhibitory activities toward DNA topoisomerase II IC50 054 14 15 077 and 3 μM respectively than the positive control etoposide IC50 44 μM Compounds 1 and 4 displayed weak cytotoxicities against human lung cancer A549 ovarian cancer SKOV3 human liver hepatoblastoma HepG2 and colon adenocarcinoma HT29 cell lines

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