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Title of Journal: Arch Pharm Res

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Abbravation: Archives of Pharmacal Research

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Pharmaceutical Society of Korea

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DOI

10.1002/ajoc.201500448

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1976-3786

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Alloxaninduced diabetic thermal hyperalgesia pro

Authors: Karim Raafat Maha AboulEla Abdalla ElLakany
Publish Date: 2014/03/26
Volume: , Issue: , Pages: 1-10
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Abstract

Rheum ribes L known as Syrian rhubarb is used in traditional Lebanese folk medicine for the treatment of diabetes The present study aims to investigate the activities of R ribes aqueous extract for glucose homeostasis in vivo antioxidant and diabetic neuropathy protection in mice The acute and the subacute effects of various doses of R ribes on blood glucose and in vivo antioxidant activity utilizing serum catalase level CAT were studied in alloxandiabetic mice The high doses significantly lowered glucose level and increased serum CAT in alloxandiabetic mice Pretreatment with the extract prior to alloxination protected the mice from acquiring diabetes and diabetic neuropathy Treatment with the extract for 8 weeks alleviated hyperalgesia in diabetic mice Our findings provide clinicians with promising drugs intended for the management of the symptoms of diabetic complications The protective activity of R ribes against acquiring diabetes and diabetic neuropathy might pave the way for preparing a prophylactic treatment for diabetes risk groups

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