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Title of Journal: Arch Pharm Res

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Abbravation: Archives of Pharmacal Research

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Pharmaceutical Society of Korea

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DOI

10.1007/978-3-642-23244-2_59

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1976-3786

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Inhibitory effect of homochlorcyclizine on melanog

Authors: TeSheng Chang ChinTsun Chen
Publish Date: 2012/02/02
Volume: 35, Issue: 1, Pages: 119-127
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Abstract

The histamine receptor H1 antagonist homochlorcyclizine HC has been widely used as an antihistamine agent for the treatment of allergies However the effect of HC on skin pigmentation is not known In the present study we investigated the inhibitory effect of HC on melanogenesis in mouse B16 melanoma cells Our results showed that HC inhibited melanogenesis in either αmelanocyte stimulating hormone αMSH or 3isobutyl1methylxanthin IBMXstimulated B16 cells in a dosedependent manner Despite the strong inhibition of melanogenesis by HC it was surprisingly found that HC did not reduce either cellular or melanosomal tyrosinase activity in αMSHstimulated B16 cells In addition HC also did not directly inhibit either murine or mushroom tyrosinase activity in the cellfree system Moreover western blotting and reversetranscription polymerase chain reaction RTPCR analyses respectively confirmed that HC did not downregulate levels of tyrosinase protein and its mRNA in αMSHstimulated B16 cells These results clearly demonstrated that HC inhibits melanogenesis of B16 cells by a mechanism other than reduction of the cellular tyrosinase activity From the present study HC was proven to be a good candidate as a skinwhitening agent for treatment of skin hyperpigmentation and this generic drug might be suitable for use in combination with other depigmenting agents due to its unique inhibition mechanism

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