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Title of Journal: Arch Pharm Res

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Abbravation: Archives of Pharmacal Research

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Pharmaceutical Society of Korea

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DOI

10.1001/jamaoto.2014.2662

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1976-3786

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Causal effects of synthetic chemicals on mitochond

Authors: WookHa Park YoungChul Kang Ying Piao Daniel Hyungseok Pak Youngmi Kim Pak
Publish Date: 2013/02/07
Volume: 36, Issue: 2, Pages: 178-188
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Abstract

It is generally accepted that mitochondrial deficits cause many common ageassociated diseases including type 2 diabetes However it has not been understood what causes mitochondrial damages and how to interrupt the development of the diseases in patients Recent epidemiologic studies demonstrated a positive correlation between serum concentrations of environmental pollutants and insulin resistance/diabetes Emerging data strongly suggest that some synthetic pollutants disturb the signaling pathway critical for energy homeostasis and insulin action The synthetic chemicals are possibly involved in pathogenesis of insulin resistance and diabetes as mitochondriadisturbing agents In this review we present a molecular scheme to address the contribution of environmental synthetic chemicals to this metabolic catastrophe Efforts to identify synthetic chemicals with mitochondriadamaging activities may open a new era to develop effective therapeutic interventions against the worldwidespreading metabolic disorder

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