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Title of Journal: Arch Pharm Res

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Abbravation: Archives of Pharmacal Research

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Pharmaceutical Society of Korea

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1976-3786

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Antiinflammatory and antinociceptive activities

Authors: Xiaohua Liu Zhenlin Hu Qirong Shi Huawu Zeng Yunheng Shen Huizi Jin Weidong Zhang
Publish Date: 2010/07/27
Volume: 33, Issue: 7, Pages: 981-987
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Abstract

Radix Tinosporae is a herb widely used in traditional Chinese medicine for the treatment of various inflammatory diseases In the present study its antiinflammatory and antinociceptive activities were investigated The ethanol extract of Radix Tinosporae exhibited significant inhibitory effects on xyleneinduced ear edema and acetic acidinduced writhing in mice Using bioassayguided fractionation the nbutanol fraction was determined as the active fraction Further purification of the most active nbutanol fraction led to the isolation of three compounds palmatine columbamine and columbinyl glucoside All three compounds showed inhibitory activities on xyleneinduced ear edema but only palmatine and columbamine exhibited significant inhibitory effects on acetic acidinduced writhing In addition palmatine and columbamine markedly inhibited in vitro production of nitric oxide and nuclear factorκB activation in RAW2647 macrophage cells in response to lipopolysaccharide or tumor necrosis factor α stimulation These results provide justification for the utilization of Radix Tinosporae in Chinese folk medicine for the treatment of inflammatory diseases

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