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Title of Journal: Arch Pharm Res

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Abbravation: Archives of Pharmacal Research

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Pharmaceutical Society of Korea

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DOI

10.1002/prac.570140149

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1976-3786

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The intracellular uptake ability of chitosancoate

Authors: BeomSu Kim CheolSang Kim KangMin Lee
Publish Date: 2008/09/12
Volume: 31, Issue: 8, Pages: 1050-
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Abstract

In this study we prepared chitosancoated Poly DLlactidecoglycolide PLGA nanoparticles Specifically we utilized a double emulsionsolvent evaporation technique to formulate nanoparticles containing paclitaxel as a model macromolecule and 6coumarin as a fluorescent marker SEM images verified that all nanoparticles were spherical in shape with smooth surfaces Chitosan coating slightly increased the size distribution of the PLGA/PVA nanoparticles from 2022 ± 32 nm to 2122 ± 29 nm but the encapsulation efficiency was not significantly different In contrast coating with chitosan slowed the in vitro drug release rate and significantly changed the zeta potential from negative −301 ± 06 mV to positive 26 ± 12 mV At the initial burst time the drug release rate from chitosancoated nanoparticles was slightly slower than that of the uncoated nanoparticles Chitosancoated nanoparticles were also taken up much more efficiently than uncoated nanoparticles This study demonstrated the efficacy of chitosancoated PLGA nanoparticles as an efficient delivery system

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