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Title of Journal: Arch Pharm Res

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Abbravation: Archives of Pharmacal Research

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Springer Netherlands

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DOI

10.1007/s002040050218

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ISSN

1976-3786

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Rhein lysinate inhibits monocyte adhesion to human

Authors: Yajun Lin Yongzhan Zhen Jiang Liu Jie Wei Ping Tu Gang Hu
Publish Date: 2013/05/25
Volume: 36, Issue: 11, Pages: 1410-1418
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Abstract

The objective of this study was to investigate the effect of rhein lysinate RHL on monocyte adhesion and its mechanism 345dimethylthiazol2yl25diphenyltetrazolium bromide MTT assay was used to determine the growth inhibition by drugs The monocyte chemoattractant protein MCP1 levels were assayed using MCP1 ELISA The expression of proteins was detected by Western blotting analysis The results indicated that RHL inhibited monocyte adhesion in a dose and timedependent manner RHL 20 μmol/L and lipopolysaccharide LPS had no effect on viability of human umbilical vein endothelial cells Therefore 20 μmol/L RHL was selected for this study RHL inhibited secretion of MCP1 induced by LPS and expression of intercellular adhesion molecule ICAM1 and vascular cell adhesion molecule VCAM1 In the meantime both RHL and p38 inhibitor SB203580 inhibited phosphorylation of p38 and mitogenactivated protein kinaseactivated protein kinase2 MAPKAPK2 and transcription and expression of ICAM1 and VCAM1 In conclusion RHL inhibits the transcription and expression of ICAM1 and VCAM1 by the p38/MAPKAPK2 signaling pathway and the effect of RHL on transcription and expression of ICAM1 and VCAM1 is similar to p38 inhibitor RHL could be a prophylactic drug for atherosclerosis

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