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Title of Journal: Arch Pharm Res

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Abbravation: Archives of Pharmacal Research

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Pharmaceutical Society of Korea

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DOI

10.1016/0169-5002(95)90276-7

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ISSN

1976-3786

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Antihyperalgesic and antiinflammatory effects of

Authors: JaeHeon Yang TaeYoul Kim JiHye Lee SeWon Yoon KyuHo Yang SangChul Shin
Publish Date: 2008/05/01
Volume: 31, Issue: 4, Pages: 511-517
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Abstract

The aim of this study was to determine if a Ketorolac Tromethamine KT gel solution could be administered in vivo via phonophoretic transdermal delivery using pulsed ultrasound by examining its antihyperalgesic and antiinflammatory effects in a rat carrageenen inflammation model 1 carrageenan was injected into the plantar surface of the right hindpaw of a rat and antihyperalgesic and antiinflammatory effects of KT via phonophoretic transdermal delivery were examined The changes in the mechanical and thermal hyperalgesia nociceptive flexor reflex NFR as well as the swelling changes were determined According to the antihyperagesia and antiinflammation tests which were used to determine the change in the pain threshold NFR and swelling showed that the group given the phonophoretic transdermal delivery of KT exhibited significantly more noticeable antihyperalgesic and antiinflammatory effects than those treated with the simple application of a KT gel The transdermal application of KT gel using phonophoresis had significant antihyperalgesic and antiinflammatory effects These findings suggest that the transdermal administration of a KT gel using phonophoresis using pulsed ultrasound might be useful for treating acute inflammation and pain

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