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Title of Journal: J Radioanal Nucl Chem

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Abbravation: Journal of Radioanalytical and Nuclear Chemistry

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Springer Netherlands

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DOI

10.1016/0378-5173(89)90040-9

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ISSN

1588-2780

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Synthesis and biodistribution of Superscript99m

Authors: Shuye Yang Xuebin Wang Haixun Guo Jian Liu Fenglong Wang Xianzhong Zhang
Publish Date: 2008/06/03
Volume: 278, Issue: 1, Pages: 165-
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Abstract

Mixed ligand factricarbonyl complex of 99mTcCO3DMSAMIBI has been prepared starting from the precursor 99mTcOH23CO3+ The complex can be obtained in good yield and purity in a twostep procedure by first attaching meso23dimercaptosuccinic acid DMSA HOOCCHSHCHSHCOOH with 99mTcOH23CO3+ followed by addition of MIBI tetrakis2methoxyisobutylisonitrile CH3OCCH32CH2N≡C copperI tetrafluoroborate solution The complex was characterized by TLC and HPLC and was studied by means of octanolwater partition coefficient electrophoresis stability in vitro and normal mice experiment Biodistribution in mice demonstrated that the complex showed higher myocardial uptake after 05hour pi The ratios of heart/liver ID/g in the case of 99mTcCO3DMSAMIBI was higher 188 than that observed in case of 99mTcMIBI1 093 after 05hour pi P005 Results showed that the complex may be developed to a novel myocardial perfusionimaging agent

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  2. Solid phase microextraction sampling of high explosive residues in the presence of radionuclides and radionuclide surrogate metals
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  7. Quantitative analysis of neodymium, uranium, and palladium in nitric acid solution by reflection absorption spectrophotometry
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  11. Modified TTA method for the determination of plutonium
  12. Application of radiometric method for element migration determination from plastic packaging to food
  13. Study of Doppler broadening of gamma-ray spectra in 14-MeV neutron activation analysis
  14. Radiological assessment of pharmaceutical clays
  15. Controllable polymerization of poly-DVB–VBC– g– AO resin via surface-initiated atom transfer radical polymerization for uranium removal
  16. Cesium uptake by Ca/Mg bentonite: evaluation of sorption experiments by a multicomponent two-site ion-exchange model
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