Authors: Ozge Er Fatma Yurt Lambrecht Kasim Ocakoglu Cagla Kayabasi Cumhur Gunduz
Publish Date: 2015/03/21
Volume: 306, Issue: 1, Pages: 155-163
Abstract
In this study the biological potential of a nickel chlorophyll derivative NiPHA as a multimodal agent for tumor imaging and photodynamic therapy PDT was investigated Optimum conditions of labeling with 131I were investigated and determined as pH 10 and 1 mg amount of iodogen Biodistribution results of 131I labeled NiPHA in female rats indicated that radiolabeled NiPHA maximum uptake in the liver spleen and ovary was observed at 30 min Intercellular uptake and PDT efficacy of NiPHA were better in MDAH2774 human ovarian endometrioid adenocarcinoma than in MCF7 human breast adenocarcinoma cells NiPHA might be a promising multimodal agent for lung ovary and liver tumor imaging and PDT
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