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Title of Journal: J Radioanal Nucl Chem

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Abbravation: Journal of Radioanalytical and Nuclear Chemistry

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Springer Netherlands

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ISSN

1588-2780

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Labeling of atenolol with radioactive iodine125 u

Authors: M ElTawoosy N Farouk A S ElBayoumy
Publish Date: 2011/06/25
Volume: 290, Issue: 3, Pages: 595-600
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Abstract

An adopted method for the preparation of high radiochemical purity 125Iatenolol was investigated Direct radioiodination of atenolol was carried out using Nbromosuccinamide or hydrogen peroxide as an oxidizing agent The reaction proceeds well within 30 min at room temperature 25 ± 1 °C and afforded a radiochemical yield up to 97 as pure as 125Iatenolol Different chromatographic techniques electrophoresis TLC and HPLC were used to determine the radiochemical yield and purity of the labeled product Biodistribution studies were carried out in normal Albino Swiss mice and the results indicate that 125Iatenolol can be used safely as myocardial imaging agent

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  13. Study of Doppler broadening of gamma-ray spectra in 14-MeV neutron activation analysis
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