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Title of Journal: J Radioanal Nucl Chem

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Abbravation: Journal of Radioanalytical and Nuclear Chemistry

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Springer Netherlands

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ISSN

1588-2780

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Local delivery of rhenium188 colloid into hepatic

Authors: LingKuen Huang WenMing Chen WanYu Lin GuoYi Gan BorTsung Hsieh
Publish Date: 2011/05/01
Volume: 290, Issue: 1, Pages: 39-44
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Abstract

A previously developed internal radiation therapy mode adopting a thermosensitive chitosanbased hydrogel intended for local delivery of 188Re–Tin colloid drug was extended to test for its applicability to the treatment of hepatoma in rats The effects of two formulations of hydrogel with different gel times and two methods of delivering the hydrogel containing 188Re–Tin colloid into tumors on the accumulated dose and duration of radioactivity within tumor were first studied by in vitro release planar scintigraphy and biodistribution evaluations Results from this initial study suggest that a treatment mode using the intratumoral delivery method and a 4 min gel time hydrogel to deliver the 188Re–Tin colloid into the tumor is more effective for treating hepatoma in rats The treatment mode was then further verified through efficacy evaluations based on hepatic tumor growth in hepatomabearing rats In conclusion the application of chitosan/βglycerophosphate C/GP hydrogel for the local delivery of 188Re–Tin colloid to treat hepatoma in rats is feasible The effective and efficient treatment mode consists of the intratumoral injection of 188Re–Tin colloid premixed with 4 min gel time C/GP hydrogel

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