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Title of Journal: Appl Biochem Biotechnol

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Abbravation: Applied Biochemistry and Biotechnology

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Humana Press Inc

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DOI

10.1007/s12010-008-8208-1

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ISSN

1559-0291

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Antimicrobial and Antineoplasic Activity of Empha

Authors: E R S Wolff E Wisbeck M L L Silveira R M M Gern M S L Pinho S A Furlan
Publish Date: 2008/10/02
Volume: 151, Issue: 2-3, Pages: 402-
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Abstract

The objectives of this work were to evaluate the antimicrobial and antineoplasic activity of Pleurotus ostreatus DSM 1833 To study the antimicrobial activity the following extracts were prepared water infusion of the fresh fruiting bodies B1 dehydrated fruiting bodies B2 fresh mycelium M1 and dehydrated mycelium M2 Polysaccharides from the fresh mycelium were also obtained by water infusion followed by ethanol treatment EP The extracts were tested against Candida albicans Escherichia coli and Bacillus subtilis To investigate the antineoplasic effect of P ostreatus the culture broth in natura the extract from the culture broth ECB and the extract from the fruiting bodies were tested in female Swiss albino mice inoculated with the Ehrlich ascitic tumor EAT B1 B2 and M1 showed more than 500 inhibition against C albicans M2 presented a high degree of inhibition against E coli 875 and B subtilis 575 while EP was not effective All the tested substances inhibited the development of EAT at levels near 70 when injected intraperitoneally in mice The highest tumor inhibition 76 was achieved for the treatment with ECB The intragastric treatment did not promote any reduction in tumor cell development independent of the test substance

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