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Title of Journal: Appl Biochem Biotechnol

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Abbravation: Applied Biochemistry and Biotechnology

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Humana Press Inc

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DOI

10.1016/j.afjem.2012.04.004

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1559-0291

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Galanthamine and Related Alkaloids Production by

Authors: Ivan Ivanov Vasil Georgiev Milen Georgiev Mladenka Ilieva Atanas Pavlov
Publish Date: 2010/07/31
Volume: 163, Issue: 2, Pages: 268-277
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Abstract

The process of galanthamine and related alkaloids production by Leucojum aestivum shoot culture in a temporary immersion system was studied It was established that temporary immersion approach is prospective for development of a biosynthetic process for obtaining valuable Amaryllidaceae alkaloids Both immersion frequency and temperature had significant effect on biomass accumulation and the yields of galanthamine and related alkaloids The maximal yield of galanthamine was achieved at the cultivation of L aestivum shoot culture in temporary immersion RITA® system at immersion frequency 15 min flooding and 8 h standby periods at 26 °C Data on the relationships in the biological system “Nutrient medium–L aestivum shoot culture–galanthamine” are presented as well

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