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Title of Journal: J Microbiol

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Abbravation: Journal of Microbiology

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Publisher

The Microbiological Society of Korea

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DOI

10.1016/0921-4526(93)90113-k

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ISSN

1976-3794

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Evaluation of a novel commercial quaternary ammoni

Authors: Yasmine Samy Elkholy Asmaa Sayed Hegab Dalia Kadry Ismail Reem Mostafa Hassan
Publish Date: 2016/01/05
Volume: 54, Issue: 1, Pages: 39-43
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Abstract

Endoscopes are a common source of outbreaks of healthcareassociated infections It is therefore important to identify highlevel disinfectants capable of eliminating or killing all vegetative bacteria mycobacteria and viruses Aldehydebased disinfectants are most commonly used in clinical practice but resistance has recently been detected and side effects associated with these disinfectants are well documented In this study we evaluated Virusolve+® EDS a novel quaternary ammonium compound formulation supplied by Amity international against Mycobacterium bovis ATCC27289 hepatitis C virus HCVpositive serum and hepatitis B surface antigenpositive serum We also compared its efficacy against Cidex® glutaraldehyde 2 an aldehydebased disinfectant M bovis showed no growth after 10 weeks with either Virusolve+® or Cidex® Virusolve+® achieved a 104 fold reduction in the initial 106 HCV load under clean conditions without red blood cells for 20 min whereas Cidex® achieved this reduction under clean and dirty conditions without and with red blood cells respectively after both 10 and 20 min Both Virusolve+® and Cidex® were able to eradicate hepatitis B virus HBV infectivity under clean conditions after 10 and 20 min whereas under dirty conditions they were only able to eradicate virus infectivity after 20 min Virusolve+® EDS when compared with Cidex® showed equal mycobactericidal activity completely eradicating M bovis However both showed comparable virucidal activity against HBV which was more effective under clean conditions emphasizing the importance of the cleaning step in endoscope reprocessing Cidex® was more effective at eradicating HCV under dirty conditions after a short contact time

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