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Title of Journal: Pediatr Nephrol

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Abbravation: Pediatric Nephrology

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Springer-Verlag

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DOI

10.1007/bf00419766

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ISSN

1432-198X

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Agerelated differences in Adriamycininduced neph

Authors: Hyewon Hahn Young Seo Park Il Soo Ha Hae Il Cheong Yong Choi
Publish Date: 2004/05/11
Volume: 19, Issue: 7, Pages: 761-766
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Abstract

We investigated the effects of age on Adriamycininduced nephropathy in mice Disease was produced by a single intravenous injection of Adriamycin doxorubicin hydrochloride AD 20 mg/kg in female Balb/C mice of 5 and 12 weeks of age Urinary protein and transforming growth factor TGFβ1 concentrations were measured and the extent of glomerular sclerosis/hyalinosis and tubulointerstitial fibrosis was scored Decorin and fibromodulin expression was quantified using reverse transcriptionpolymerase chain reaction In normal mouse kidneys urinary TGFβ1 excretion and decorin and fibromodulin mRNA did not change with age When nephropathy was induced the 12weekold group demonstrated significantly greater proteinuria urinary TGFβ1 excretion and interstitial fibrosis P005 than the 5weekold group Decorin and fibromodulin expression was not significantly different between the groups We conclude that 12weekold mice develop more severe nephropathy than the younger mice following administration of the equivalent weightbased dose of AD Decorin and fibromodulin do not play a role in this difference

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