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Title of Journal: Pediatr Nephrol

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Abbravation: Pediatric Nephrology

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Springer-Verlag

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DOI

10.1007/bf00623021

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1432-198X

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Rhabdomyolysis pathogenesis of renal injury and m

Authors: Zubaida AlIsmaili Melissa Piccioni Michael Zappitelli
Publish Date: 2011/01/20
Volume: 26, Issue: 10, Pages: 1781-1788
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Abstract

Rhabdomyolysis refers to the breakdown of skeletal muscle due to either a physical biological or toxic injury that leads to leakage of muscle contents such as myoglobin and creatinine kinase CK into the extracellular fluid This syndrome is classically characterized clinically by muscle weakness and pain and at times teacolored urine Serum myoglobin is filtered by the glomerulus leading to myoglobinuria This may lead to direct renal tubular injury and a clinical presentation ranging from mild to lifethreatening acute kidney injury AKIRhabdomyolysis was described as early as biblical times However it was during the London bombings in World War II that the link between rhabdomyolysis and AKI was described in crush victims 1 followed by similar reports from other wars 2 3 Much later nonphysical injuries were recognized as potential causes of rhabdomyolysis Limited data exist on rates of rhabdomyolysis in

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  2. Abdominal pain in a female adolescent: answer
  3. Simvastatin ameliorates glomerulosclerosis in Adriamycin-induced-nephropathy rats
  4. Henoch-Schönlein purpura nephritis with nephrotic state in children: predictors of poor outcomes
  5. CFH gene mutation in a case of Shiga toxin-associated hemolytic uremic syndrome (STEC-HUS)
  6. Vincristine treatment in steroid-dependent nephrotic syndrome
  7. Roles of renal ammonia metabolism other than in acid–base homeostasis
  8. Catastrophic antiphospholipid antibody syndrome
  9. Congenital nephrotic syndrome with prolonged renal survival without renal replacement therapy
  10. Long-term outcome of children treated with rituximab for idiopathic nephrotic syndrome
  11. The clinical and laboratory features of Chinese Han anti-factor H autoantibody-associated hemolytic uremic syndrome
  12. Erratum to: Health-related quality of life and mental health in parents of children with hemolytic uremic syndrome
  13. Erratum to: Health-related quality of life and mental health in parents of children with hemolytic uremic syndrome
  14. Success of eculizumab in the treatment of atypical hemolytic uremic syndrome
  15. Fungal peritonitis in children on peritoneal dialysis
  16. A case of dense deposit disease associated with a group A streptococcal infection without the involvement of C3NeF or complement factor H deficiency
  17. Intravenous delivery of cysteamine for the treatment of cystinosis: association with hepatotoxicity
  18. An unusual cause of pleural effusion, urinothorax in a child with urinary stone disease
  19. Genetic polymorphisms and risk for acute renal failure in preterm neonates
  20. Outcome of dialysis in children with human immunodeficiency virus infection
  21. Outcome after renal transplantation. Part I: Intellectual and motor performance
  22. International validation of a urinary biomarker panel for identification of active lupus nephritis in children
  23. Macrovascular involvement in a child with atypical hemolytic uremic syndrome
  24. An infant presenting with a non-functional kidney on dimercaptosuccinic acid scan: question
  25. Maternal diabetes programs hypertension and kidney injury in offspring
  26. Nutritional management and growth in children with chronic kidney disease
  27. Hypertension and hemodialysis: pathophysiology and outcomes in adult and pediatric populations
  28. Age-related differences in Adriamycin-induced nephropathy
  29. Pattern of double glomerulopathy in children
  30. Growth after renal transplantation in infancy or early childhood
  31. Re-establishment of the ERA-EDTA Registry
  32. Primary hyperoxalurias: diagnosis and treatment
  33. Treatment of Wilms tumor-related hypertension with losartan and captopril
  34. NOx (nitrite/nitrate) in patients with pediatric nephrotic syndrome
  35. Vitamin D deficiency and parathyroid hormone levels following renal transplantation in children
  36. Circulating factor in FSGS: a black sheep in the suPAR family?
  37. Renin–angiotensin II–aldosterone system blockers and time to renal replacement therapy in children with CKD
  38. Factors affecting histological regression of crescentic Henoch–Schönlein nephritis in children
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  40. The BK virus in renal transplant recipients—review of pathogenesis, diagnosis, and treatment
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  42. Longitudinal growth in chronic hypokalemic disorders
  43. Sonic tooth brushing reduces gingival overgrowth in renal transplant recipients
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  48. Utility of fractional excretion of urea in the differential diagnosis of acute kidney injury in children
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  60. Tissue factor pathway inhibitor in childhood nephrotic syndrome
  61. Sodium and potassium clearances by the maturing kidney: clinical-molecular correlates
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  63. Serum calcium values in term and late-preterm neonates receiving gentamicin
  64. Can office blood pressure readings predict masked hypertension?
  65. Searching the optimal PTH target range in children undergoing peritoneal dialysis: New insights from international cohort studies
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