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Title of Journal: Pediatr Nephrol

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Abbravation: Pediatric Nephrology

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Springer-Verlag

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DOI

10.1002/eji.1830270103

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1432-198X

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Crescentic glomerulonephritis in a child with infe

Authors: Banu Sadikoglu Ilmay Bilge Isin Kilicaslan Muge G Gokce Sevinc Emre Turkan Ertugrul
Publish Date: 2006/04/20
Volume: 21, Issue: 6, Pages: 867-
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Abstract

Renal manifestations associated with infective endocarditis IE may present with different clinical patterns and the most common renal histopathological finding is diffuse proliferative and exudative type of glomerulonephritis leading to hematuria and/or proteinuria Renal failure due to crescentic glomerulonephritis CGN in children with IE is a very rare condition We report here a 6yearold boy who had a history of cardiac surgery for pulmonary atresia and ventricular septal defect presenting with the clinical findings of IE and hematuria associated with renal failure due to CGN He was treated with a combination of intravenous IV methylprednisolone pulses and appropriate antibiotics but also received one dose of IV cyclophosphamide Complete serological biochemical and clinical improvement was achieved after 2 months of followup Antibiotic therapy is the essential part of the treatment of IEassociated glomerulonephritis however this case also highlights the importance of aggressive immunosuppressive therapy to suppress the immunological process related with infection in this lifethreatening condition leading to renal failure

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