Authors: Giuseppina Spartà Markus J Kemper Thomas J Neuhaus
Publish Date: 2006/09/01
Volume: 21, Issue: 12, Pages: 1884-1888
Abstract
Hyperuricemia and gout are common complications in adult renal transplant recipients In pediatric recipients however hyperuricemia seems to be rare but data are scarce Thirtytwo children 21 males 11 females were investigated for a median time of 48 years range 04–112 years following renal transplantation The median age of this pediatric study group was 139 years range 57–203 years and the calculated glomerular filtration rate GFR was 61 ml/min per 173 m2 range12–88 ml/min per 173 m2 All patients were given calcineurin inhibitors with 22 and ten children receiving cyclosporine A CSA and tacrolimus TAC respectively The median plasma uric acid was 385 μmol/l range 62–929 μmol/l 15 children 47 were above the agerelated normal range Only one patient experienced gouty arthritis There was a significant correlation between plasma uric acid concentration and both time span after transplantation and plasma creatinine and an inverse correlation to GFR p005 No significant correlation was found between plasma uric acid and body mass index BMI Plasma uric acid concentrations were neither different among CSA and TACtreated children nor did they correlate with drug exposure or blood trough levels of CSA or TAC Plasma uric acid concentration was not different when compared to children with chronic renal failure CRF of a similar degree in native kidneys We conclude that hyperuricemia is common among pediatric renal transplant recipients and rather a consequence of chronic renal transplant dysfunction than the use of calcineurin inhibitors Gout however is rare
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