Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Pediatr Nephrol

Search In Journal Title:

Abbravation: Pediatric Nephrology

Search In Journal Abbravation:

Publisher

Springer-Verlag

Search In Publisher:

DOI

10.1002/pssa.200404904

Search In DOI:

ISSN

1432-198X

Search In ISSN:
Search In Title Of Papers:

IgG subclasses and complement pathway in segmental

Authors: Yoshie Segawa Satoshi Hisano Misao Matsushita Teizo Fujita Shinichi Hirose Morishige Takeshita Hiroshi Iwasaki
Publish Date: 2010/02/12
Volume: 25, Issue: 6, Pages: 1091-1099
PDF Link

Abstract

The aim of our study was to clarify the association between immunoglobulin GIgG subclasses and the complement pathway in patients with idiopathic membranous nephropathy MN Immunofluorescence IF was performed in 16 MN patients and 20 controls using antibodies against IgG IgA IgM C1q C3c C4d IgG1 IgG2 IgG3 IgG4 mannose binding lectin MBL C4binding protein C4bp factor B C5b9 and CD59 MN was classified into two types segmental MN SMN six patients and global MN GMN ten patients according to the distribution of IgG deposits along the glomerular capillary wall No deposition of any antibody was found in the controls IF revealed IgG1 IgG3 C1q C3c C4d C4bp C5b9 and CD59 deposits in patients with SMN whereas IgG1 IgG2 IgG3 IgG4 C3c C4d MBL factor B C4bp C5b9 and CD59 deposits were detected in those with GMN There was a higher deposition of IG1 IgG2 and IgG4 in patients with GMN than in those with SMN whereas the intensity of C1q deposits was higher in SMN than in GMN patients In contrast the intensity of factor B and MBL was higher in GMN than in SMN patients This is the first report of SMN patients showing complement activation of the classical pathway associated with IgG1 and IgG3 and GMN patients showing complement activation of both the alternative and lectin pathways associated with IgG2 and IgG4

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Chronic kidney disease after liver, cardiac, lung, heart–lung, and hematopoietic stem cell transplant
  2. Abdominal pain in a female adolescent: answer
  3. Simvastatin ameliorates glomerulosclerosis in Adriamycin-induced-nephropathy rats
  4. Henoch-Schönlein purpura nephritis with nephrotic state in children: predictors of poor outcomes
  5. CFH gene mutation in a case of Shiga toxin-associated hemolytic uremic syndrome (STEC-HUS)
  6. Vincristine treatment in steroid-dependent nephrotic syndrome
  7. Roles of renal ammonia metabolism other than in acid–base homeostasis
  8. Catastrophic antiphospholipid antibody syndrome
  9. Congenital nephrotic syndrome with prolonged renal survival without renal replacement therapy
  10. Rhabdomyolysis: pathogenesis of renal injury and management
  11. Long-term outcome of children treated with rituximab for idiopathic nephrotic syndrome
  12. The clinical and laboratory features of Chinese Han anti-factor H autoantibody-associated hemolytic uremic syndrome
  13. Erratum to: Health-related quality of life and mental health in parents of children with hemolytic uremic syndrome
  14. Erratum to: Health-related quality of life and mental health in parents of children with hemolytic uremic syndrome
  15. Success of eculizumab in the treatment of atypical hemolytic uremic syndrome
  16. Fungal peritonitis in children on peritoneal dialysis
  17. A case of dense deposit disease associated with a group A streptococcal infection without the involvement of C3NeF or complement factor H deficiency
  18. Intravenous delivery of cysteamine for the treatment of cystinosis: association with hepatotoxicity
  19. An unusual cause of pleural effusion, urinothorax in a child with urinary stone disease
  20. Genetic polymorphisms and risk for acute renal failure in preterm neonates
  21. Outcome of dialysis in children with human immunodeficiency virus infection
  22. Outcome after renal transplantation. Part I: Intellectual and motor performance
  23. International validation of a urinary biomarker panel for identification of active lupus nephritis in children
  24. Macrovascular involvement in a child with atypical hemolytic uremic syndrome
  25. An infant presenting with a non-functional kidney on dimercaptosuccinic acid scan: question
  26. Maternal diabetes programs hypertension and kidney injury in offspring
  27. Nutritional management and growth in children with chronic kidney disease
  28. Hypertension and hemodialysis: pathophysiology and outcomes in adult and pediatric populations
  29. Age-related differences in Adriamycin-induced nephropathy
  30. Pattern of double glomerulopathy in children
  31. Growth after renal transplantation in infancy or early childhood
  32. Re-establishment of the ERA-EDTA Registry
  33. Primary hyperoxalurias: diagnosis and treatment
  34. Treatment of Wilms tumor-related hypertension with losartan and captopril
  35. NOx (nitrite/nitrate) in patients with pediatric nephrotic syndrome
  36. Vitamin D deficiency and parathyroid hormone levels following renal transplantation in children
  37. Circulating factor in FSGS: a black sheep in the suPAR family?
  38. Renin–angiotensin II–aldosterone system blockers and time to renal replacement therapy in children with CKD
  39. Factors affecting histological regression of crescentic Henoch–Schönlein nephritis in children
  40. The R229Q mutation in NPHS2 may predispose to proteinuria in thin-basement-membrane nephropathy
  41. The BK virus in renal transplant recipients—review of pathogenesis, diagnosis, and treatment
  42. Patterning and early cell lineage decisions in the developing kidney: the role of Pax genes
  43. Longitudinal growth in chronic hypokalemic disorders
  44. Sonic tooth brushing reduces gingival overgrowth in renal transplant recipients
  45. Is genetic testing of healthy pre-symptomatic children with possible Alport syndrome ethical?
  46. Genetic polymorphisms influence the steroid treatment of children with idiopathic nephrotic syndrome
  47. Severe neutropenia in children after renal transplantation: incidence, course, and treatment with granulocyte colony-stimulating factor
  48. Discrepancies in office and ambulatory blood pressure in adolescents: help or hindrance?
  49. Utility of fractional excretion of urea in the differential diagnosis of acute kidney injury in children
  50. Evaluation of certain constituents of antioxidant defense in youth treated in the past for steroid-sensitive idiopathic nephrotic syndrome
  51. Mizoribine for renal sarcoidosis: effective steroid tapering and prevention of recurrence
  52. The IL-6 −174G/C polymorphism and renal scarring in children with first acute pyelonephritis
  53. Neurological involvement in a child with atypical hemolytic uremic syndrome
  54. Unusual cause of anemia in a child with end-stage renal disease: Questions
  55. Uraemic vasculopathy in children with chronic kidney disease: prevention or damage limitation?
  56. Oral-ibuprofen-induced acute renal failure in a preterm infant
  57. Utility and cost of a renal transplant transition clinic
  58. Hyperuricemia and gout following pediatric renal transplantation
  59. Retinoic acid may increase the risk of bone marrow transplant nephropathy
  60. Vitamin E therapy in IgA nephropathy: a double-blind, placebo-controlled study
  61. Tissue factor pathway inhibitor in childhood nephrotic syndrome
  62. Sodium and potassium clearances by the maturing kidney: clinical-molecular correlates
  63. Atypical relapse of hemolytic uremic syndrome after transplantation
  64. Serum calcium values in term and late-preterm neonates receiving gentamicin
  65. Can office blood pressure readings predict masked hypertension?
  66. Searching the optimal PTH target range in children undergoing peritoneal dialysis: New insights from international cohort studies
  67. Anthropometric risk factors for elevated blood pressure in adolescents in Turkey aged 11–17
  68. High prevalence of elevated blood pressure among children with neurofibromatosis type 1
  69. The role of the kidney and the sympathetic nervous system in hypertension
  70. Cinacalcet as adjunctive therapy in pseudohypoparathyroidism type 1b
  71. Steroid-resistant nephrotic syndrome: long-term evolution after sequential therapy
  72. Peritoneal–pericardial communication in an adolescent on peritoneal dialysis
  73. Hereditary nephrotic syndrome: a systematic approach for genetic testing and a review of associated podocyte gene mutations
  74. Endothelial nitric oxide synthase gene intron 4 a/b VNTR polymorphism in children with APSGN
  75. Successful treatment of DEAP-HUS with eculizumab
  76. Crescentic glomerulonephritis in a child with infective endocarditis
  77. Early risk factors for neonatal mortality in CAKUT: analysis of 524 affected newborns
  78. Acute acalculous cholecystitis in a child with systemic lupus erythematosus
  79. Febrile urinary tract infection in children: ampicillin and trimethoprim insufficient as empirical mono-therapy
  80. Therapeutic strategies to slow chronic kidney disease progression
  81. WT1 and glomerular diseases
  82. Blood pressure control in pediatric hemodialysis: the Midwest Pediatric Nephrology Consortium Study
  83. Renal involvement in the immunodysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) disorder
  84. Weight or body surface area dosing of steroids in nephrotic syndrome: is there an outcome difference?
  85. Determination of urinary calculi by binocular stereoscopic microscopy
  86. The use of darbepoetin in infants with chronic renal impairment
  87. Bone metabolism in oxalosis: a single-center study using new imaging techniques and biomarkers
  88. Weight or body surface area dosing of steroids in nephrotic syndrome: is there an outcome difference?
  89. The use of darbepoetin in infants with chronic renal impairment
  90. Maximizing the sensitivity of the indirect radionuclide cystogram: a retrospective audit
Search Result: