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Title of Journal: Pediatr Nephrol

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Abbravation: Pediatric Nephrology

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Springer-Verlag

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DOI

10.1007/bf01295178

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1432-198X

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NOx nitrite/nitrate in patients with pediatric n

Authors: Hisashi Kawashima Yasuyo Kashiwagi Chiako Watanabe Satoshi Sato Shigeo Nishimata Kouji Takekuma Akinori Hoshika Yasuo Watanabe
Publish Date: 2007/02/08
Volume: 22, Issue: 6, Pages: 840-843
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Abstract

To better understand the role of nitric oxide NO in pediatric nephrotic syndrome we measured nitrite/nitrate NOx left textNO 2 textandtextNO 3 right in serum obtained from patients with several pediatric kidney diseases and investigated the locations of endothelial nitric oxide synthase eNOS and inducible nitric oxide synthase iNOS NOx in serum showed significantly higher levels than those in healthy controls mean ± SE 297 ± 557 vs 158 ± 131 pmol/10 μl There was no significant difference between six patients with frequent relapse and five patients with nonfrequent relapse The studies with immunostaining of iNOS and nitrotyrosine were negative for glomerulus in patients with nephrotic syndrome Those findings suggest that NOx might indirectly influence disease progression in nephrotic syndrome

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