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Title of Journal: Pediatr Nephrol

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Abbravation: Pediatric Nephrology

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Springer-Verlag

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DOI

10.1006/jcis.1995.1299

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1432-198X

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Maternal diabetes programs hypertension and kidney

Authors: YunWen Chen Isabelle Chenier Stella Tran Michael Scotcher ShiaoYing Chang ShaoLing Zhang
Publish Date: 2010/04/27
Volume: 25, Issue: 7, Pages: 1319-1329
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Abstract

We investigated whether maternal diabetes programs the offspring to develop hypertension and kidney injury in adulthood and examined potential underlying mechanisms In a murine model we studied the offspring of three groups of dams nondiabetic diabetic and diabetic treated with insulin Mean systolic blood pressure in the offspring was monitored from 8 to 20 weeks Body and kidney weights in the offspring of diabetic mothers were significantly lower than in offspring of nondiabetic mothers Offspring of diabetic mothers developed hypertension microalbuminuria and glucose intolerance Increased accumulation of extracellular matrix proteins in the glomeruli and marked upregulation of angiotensinogen angiotensin II type 1 receptor angiotensinconverting enzyme transforming growth factor beta1 TGFβ1 and plasminogen activator inhibitor1 PAI1 gene expression were evident in the renal cortex of hypertensive offspring of diabetic mothers By contrast angiotensinconverting enzyme2 ACE2 gene expression was lower in the hypertensive offspring of diabetic mothers than in that of nondiabetic mothers These changes were prevented in the offspring of insulintreated diabetic mothers These data indicate that maternal diabetes induces perinatal programming of hypertension renal injury and glucose intolerance in the offspring and suggest a central role for the activation of the intrarenal renin–angiotensin system and TGFβ1 gene expression in this process

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