Authors: Howard Trachtman Changli Wei Jochen Reiser
Publish Date: 2013/04/10
Volume: 28, Issue: 7, Pages: 1151-1152
Abstract
The observation that total suPAR levels are elevated in the majority of pediatric and adult patients with FSGS as well as in animal models that develop glomerulopathy in response to pathogenic suPAR fragments has sparked innovative research in this important disease with considerable unmet medical needs Indeed more data have recently been published that evaluated suPAR in FSGS and confirm a link between the circulating molecule in this glomerular disorderA fundamental notion in FSGS is the potential recurrence of disease after renal transplantation Like FSGS in the native kidney recurrent FSGS manifests at the level of the podocyte the presumptive locus of disease in FSGS Given the rapid onset of recurrent FSGS that can occur
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