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Title of Journal: Pediatr Nephrol

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Abbravation: Pediatric Nephrology

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Springer-Verlag

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DOI

10.1007/s11926-008-0075-9

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1432-198X

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Simvastatin ameliorates glomerulosclerosis in Adri

Authors: Wei Zhang Qiu Li Lijia Wang Xiqiang Yang
Publish Date: 2008/09/13
Volume: 23, Issue: 12, Pages: 2185-2194
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Abstract

The aim of this study was to investigate the effects of simvastatin a competitive inhibitor of 3hydroxy3methylglutarylcoenzyme A HMGCoA reductase on inflammation and glomerulosclerosis in Adriamycin ADRinduced nephropathy Male SpragueDawley rats were randomly divided into control ADR nephrosis and simvastatintreated ADR nephrosis groups ADR nephropathy was induced by a singletail intravenous injection of ADR 65 mg/kg Antiinflammatory effects of simvastatin were studied by evaluating the expression of the inflammatory mediators interleukin1 beta IL1β transforming growth factorβ1 TGFβ1 and transcription factor nuclear factor kappa B NFκB In addition renal function serum lipid levels and histopathology were compared between groups Simvastatin significantly decreases IL1β and TGFβ1 expression and NFκB activation accompanied by significant attenuation of glomerulosclerosis and renal function at 12 weeks after ADR injection and these changes occurred in the absence of lowering of serum lipids These results suggest that overexpression of inflammation in the renal region may contribute to development of glomerulosclerosis in ADRinducednephropathy rats and simvastatin treatment prevented glomerulosclerosis independent of the lipidlowering effects The beneficial effect of simvastatin might be mediated by the effect of antiinflammatory action through a reduction of NFκB activation and IL1β and TGFβ expression

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