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Title of Journal: Pediatr Nephrol

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Abbravation: Pediatric Nephrology

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Springer-Verlag

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DOI

10.1002/fedr.19180150808

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1432-198X

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Bone metabolism in oxalosis a singlecenter study

Authors: Justine Bacchetta Sonia Fargue Stéphanie Boutroy Odile Basmaison Nicolas Vilayphiou Ingrid Plotton Fitsum GuebreEgziabher Bruno Dohin Rémi Kohler Pierre Cochat
Publish Date: 2010/03/06
Volume: 25, Issue: 6, Pages: 1081-1089
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Abstract

The deposition of calcium oxalate crystals in the kidney and bone is a hallmark of primary hyperoxaluria type 1 PH1 We report here an evaluation of the bone status of 12 PH1 children based on bone biomarkers parathyroid hormone vitamin D fibroblast growth factor 23 FGF23 and radiological assessments skeletal age threedimensional highresolution peripheral quantitative computed tomography HRpQCT carried out within the framework of a crosssectional singlecenter study The controls consisted of healthy and children with chronic kidney disease already enrolled in local bone and mineral metabolism studies The mean age ±standard deviation age of the patients was 99 ±63 months Six children suffered from fracture Bone maturation was accelerated in five patients four of whom were 5 years The combination of new imaging techniques and biomarkers highlighted new and unexplained features of PH1 advanced skeletal age in young PH1 patients increased FGF23 levels and decreased total volumetric bone mineral density with bone microarchitecture alterationWe thank Dr Francois Parant Fédération de Biochimie Hôpital Edouard Herriot Lyon France for assistance in the biological aspects and Pr Yves Le Bouc INSERM 513 Hôpital Saint Antoine Paris France and Pr Pierre Chatelain Hôpital Femme Mère Enfant Bron France for their help in the interpretation of IGF1 abnormalities This work was presented at the 2008 European Society for Paediatric Nephrology Lyon at the 2009 11th international symposium on urolithiasis Nice and at the 2009 International Pediatric Nephrology Association 8th Symposium on Growth and Nutrition in CKD children Oviedo The study was supported by a 2007 Société Française de Pédiatrie/Archives de Pédiatrie educational grant This work is dedicated to Professor Pierre Delmas deceased

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