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Title of Journal: Pediatr Nephrol

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Abbravation: Pediatric Nephrology

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Springer-Verlag

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DOI

10.1007/s00735-015-0482-x

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1432-198X

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Tissue factor pathway inhibitor in childhood nephr

Authors: Mohamed M AlMugeiren Abdel Galil M Abdel Gader Saud A AlRasheed Abdullah A AlSalloum
Publish Date: 2006/03/31
Volume: 21, Issue: 6, Pages: 771-
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Abstract

It is now recognised that the extrinsic tissue factor pathway is the main trigger to the coagulation system in vivo Its main inhibitor tissue factor pathway inhibitor TFPI has never been studied in childhood nephrotic syndrome The aim of the study was to monitor the level of TFPI in childhood nephrotic syndrome One hundred and thirtynine nephrotic children were classified into the following groups group 1 n=25 in relapse and receiving no treatment group 2 n=37 in relapse but receiving steroid treatment group 3 n= 45 in early remission and on steroids group 4 n=24 in established remission and receiving no steroids group 5 n=8 steroidresistant The controls n=84 were healthy and agematched There was significant elevation of total TFPI levels in groups 1 and 2 and 3 levels were comparable to those of the healthy controls in group 4 The highest levels of total TFPI were recorded in group 5 Like total TFPI the levels of the free form of TFPI showed a statistically significant increase in groups 1 2 3 and 4 when compared with levels in healthy controls The highest levels of free TFPI were recorded group 5 We concluded that the elevated levels of both the total and free TFPI in various phases of nephrotic syndrome add another natural anticoagulant mechanism which will attenuate the hypercoagulability of childhood nephrotic syndromeWe are grateful to Mr MA Hamid Mr Lugman AG ElSid and Mrs MC Aradillous for their technical assistance to Mr Amir Abdul Aziz for statistical help and to Mrs F Chatila for her secretarial work This work was supported by a grant no AT 18–73 from King Abdul Aziz City for Science and Technology KACST Riyadh Saudi Arabia

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