Authors: Hasan Dursun Aytul Noyan Selcuk Matyar Mithat Buyukcelik Mustafa Soran Nurcan Cengiz Gulsah Seydaoglu Gulen Attila Aysun K Bayazit Ali Anarat
Publish Date: 2006/08/29
Volume: 21, Issue: 11, Pages: 1661-1665
Abstract
The role of endothelial nitric oxide synthase gene intron 4 a/b eNOS4a/b variable number of tandem repeats VNTR polymorphism in various renal diseases was investigated We investigated whether the eNOS4a/b VNTR polymorphism is associated with susceptibility to acute poststreptococcal glomerulonephritis APSGN and its clinical features Endothelial NOS4a/b VNTR polymorphism is determined by the polymerase chain reaction in 60 children with APSGN and 66 healthy controls The genotype distribution of eNOS4 does not differ between the patients and the controls X2=51 p=0079 However the frequency of eNOS4a eNOS4a/a and eNOS4a/b genotype is higher in the patients than in the controls X2=45 p=0046 In the APSGN group we performed renal biopsy on eight patients because of nephrotic syndrome accompanies acute nephritic syndrome or glomerular filtration rate GFR is lower than 50 of normal and found that to carry a/a and a/b genotypes were a significant risk factor for this type presentation OR=173 95 CI19515267 p=003 Mean serum creatinine values are found statistically significantly higher in a/a and a/b genotypes when compared with b/b genotypes p=0022 Children carrying the “aa” and “ab” genotype or “a” allele of eNOS4 have a greater tendency to develop and clinical presentation of APSGN
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