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Title of Journal: Pediatr Nephrol

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Abbravation: Pediatric Nephrology

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Springer-Verlag

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DOI

10.1002/cne.21934

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1432-198X

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Genetic polymorphisms influence the steroid treatm

Authors: YeeHsuan Chiou LinYu Wang TzuHui Wang Shiaoping Huang
Publish Date: 2012/05/20
Volume: 27, Issue: 9, Pages: 1511-1517
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Abstract

Idiopathic nephrotic syndrome INS is the most frequent type of nephrotic syndrome that occurs in children Its response to treatment with steroids varies The aim of this study was to analyze the correlation between steroid metabolismrelated genes and the response to steroid treatmentThe patient cohort comprised 74 children with INS of whom were 58 steroidsensitive SS cases and 16 steroidresistant SR cases The genetic polymorphisms analyzed were those of the CYP3A5 gene A6986G and ABCB1 gene C1236T G2677T/A and C3435T and the polymorphisms between SS and SR children were comparedC1236T in ABCB1 was associated with steroid resistance in INS children odds ratio OR 265 95  confidence interval CI 101–694 p = 0042 The frequency of the T allele was significantly higher in SR subjects than in SS subjects 081 vs 062 respectively A6986G in CYP3A5 showed a trend of association but this association did not reach statistical significance OR 263 95  CI 094–737 p = 0059 No significant correlation was found between treatment response and G2677T/A or C3435T in ABCB1Our results indicate that among our pediatric patients with INS the C1236T polymorphism in the ABCB1 gene was associated with steroid resistance while the A6986G polymorphism in the CYP3A5 gene showed a trend of association but did not reach statistical significance requiring further analysis

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