Authors: Maria Hanna Kniażewska Anna Karolina Obuchowicz Tomasz Wielkoszyński Joanna ŻmudzińskaKitczak Katarzyna Urban Lidia HylaKlekot
Publish Date: 2009/07/28
Volume: 24, Issue: 11, Pages: 2187-2192
Abstract
Disorders of lipid metabolism and antioxidant defense capacity reported during idiopathic nephrotic syndrome INS exacerbations are known The aim of this study was to evaluate constituents of antioxidant defense total antioxidant potential ferricreducing antioxidant power FRAP paraoxonase1 PON1 tocopherols ascorbic acid in patients formerly treated for INS The studied group consisted of 30 patients 20 males and 10 females treated 4–15 years ago for INS The control group consisted of 30 healthy teenagers There were no statistically significant differences in PON1 activity 1564 ± 971 vs 1377 ± 802 U/l αtocopherol levels 239 ± 73 vs 224 ± 32 µmol/l and sum of β and γtocopherols 21 ± 10 vs 23 ± 06 µmol/l and in FRAP 4849 ± 872 vs 4528 ± 769 µmol/l between groups In the study group a significantly lower concentration of ascorbic acid 530 ± 208 vs 694 ± 16 µmol/l p 0002 decreased values of αtocopherol/cholesterol 49 ± 07 vs 55 ± 12 p = 003 and total tocopherol/cholesterol 53 ± 08 vs 61 ± 14 p = 0016 ratios were observed A positive correlation between tocopherol/total cholesterol TCh r = 041 p 005 and αtocopherol/TCh r = 050 p 0001 ratios and INS relapse frequency was reported The relationship between the study parameters and group of variables relapse frequency duration of the last remission age gender was tested using the multiple linear regression analysis The results of this study suggest that the nonenzymatic antioxidant defense in young persons formerly treated for INS is weaker than in their healthy counterparts
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