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Title of Journal: Pediatr Nephrol

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Abbravation: Pediatric Nephrology

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Springer-Verlag

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DOI

10.1007/bf01794333

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1432-198X

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Factors affecting histological regression of cresc

Authors: Jae Il Shin Jee Min Park Ji Hong Kim Jae Seung Lee Hyeon Joo Jeong
Publish Date: 2005/11/04
Volume: 21, Issue: 1, Pages: 54-59
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Abstract

To identify the factors affecting histological regression of crescentic Henoch–Schönlein nephritis HSN we retrospectively analyzed serially biopsied 20 children with crescentic HSN treated with immunosuppressants They were classified into two groups according to the histological changes between the first and second biopsy group I n=10 with histological regression and group II n=10 with no change or histological progression Of the 20 patients 19 showed a favorable outcome at the end of followup Initial laboratory and histological findings did not differ between the two groups Histological regression was associated with a younger age at onset P=0003 early treatment with immunosuppressants P=0044 and absent or decreased fibrinogen deposits at the second biopsy P00001 in a univariate analysis Mesangial IgA and fibrinogen depositions at the second biopsy were reduced significantly in group I P005 In the multivariate analysis a younger age was an independent determinant of histological regression OR 144 95 CI 103–202 The intensity of fibrinogen deposits at the second biopsy correlated positively with the age at onset r=0503 P=0024 and the chronicity index at the second biopsy correlated positively with the time that immunosuppressive therapy was started r=0619 P=0004

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