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Title of Journal: Pediatr Nephrol

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Abbravation: Pediatric Nephrology

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Springer-Verlag

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DOI

10.1007/s10827-016-0608-6

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1432-198X

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Pattern of double glomerulopathy in children

Authors: Hae Il Cheong Hee Yeon Cho Kyung Chul Moon Il Soo Ha Yong Choi
Publish Date: 2006/11/16
Volume: 22, Issue: 4, Pages: 521-527
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Abstract

Occasional case reports have been issued on children with double glomerulopathy involving either the coexistence of two different glomerulopathies or superimposition of a second glomerulopathy onto a first A retrospective clinicopathological review of 294 children who had received renal biopsies resulted in 9 31 being confirmed to have double glomerulopathy Superimposed glomerulopathy was diagnosed by a second renal biopsy in two cases and coexistence of two glomerulopathies was confirmed by single biopsy in seven Original glomerulopathies were those with a chronic course such as Alport syndrome IgA nephropathy relapsing minimalchange nephrotic syndrome Frasier syndrome and thin basement membrane nephropathy The superimposing glomerulopathies were common types in children such as postinfectious glomerulonephritis IgA nephropathy and HenochSchönlein nephritis Thus the pattern of double glomerulopathy was considered to be due to the chance occurrence of two different glomerulopathies without a common pathogenesis Acute nephritic symptoms of superimposed glomerulopathies resolved almost completely during followup in most cases Double glomerulopathies are not rare in children and may occur by chance alone in most cases The possibility of superimposed glomerulopathy should be suspected if the clinical course of a glomerulopathy changes atypically However the longterm influence of a superimposed glomerulopathy on renal functional deterioration remains unclear

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