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Title of Journal: Pediatr Nephrol

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Abbravation: Pediatric Nephrology

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Springer-Verlag

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DOI

10.1016/0141-0229(94)90115-5

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1432-198X

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Mizoribine for renal sarcoidosis effective steroi

Authors: Shuichi Ito Tomonori Harada Tomoko Nakamura Tomoyuki Imagawa Kiyotaka Nagahama Takeshi Sasaki Shuichiro Fujinaga Yukoh Aihara Shumpei Yokota
Publish Date: 2008/09/13
Volume: 24, Issue: 2, Pages: 411-414
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Abstract

Sarcoidosis is a systemic disease of unknown etiology that is characterized by chronic noncaseating granulomatous inflammation with tissue destruction It is an uncommon disease in children and renal sarcoidosis in particular is very rare in adults and children A 17yearold boy with renal sarcoidosis was referred to our hospital with an initial diagnosis of pyelonephritis Prior treatment with various antibiotics had not been effective but tentative oral daily prednisolone PSL had partially ameliorated his symptoms although the symptoms recurred during steroid tapering We detected noncaseating granulomatous interstitial nephritis and numerous sclerotic glomeruli in a second biopsy specimen compatible with the diagnosis of renal sarcoidosis The patient was treated with pulsed methylprednisolone and oral daily doses of PSL and mizoribine MZR During the treatment with MZR the PSL was successfully tapered and the patient has since presented no signs of recurrence Our treatment of this patient shows that treatment with MZR can allow steroid sparing and prevent recurrence in a patient with sarcoidosis

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