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Title of Journal: Bull Exp Biol Med

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Abbravation: Bulletin of Experimental Biology and Medicine

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Publisher

Springer US

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ISSN

1573-8221

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Modification and clearance of low density lipoprot

Authors: Ya Sh Schvartz L M Polyakov M I Dushkin E N Pivovarova
Publish Date: 2008/09/26
Volume: 145, Issue: 4, Pages: 430-432
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Abstract

Changes in electrical charge and clearance rate of LDL after the formation of their complexes with bacterial LPS were studied in experiments on Wistar rats It was found that binding of S minnesota R595 LPS with 125ILDL sharply accelerated clearance of the greater part of LDL complexes but on the other hand induced the appearance of an LDLLPS subfraction with slower elimination rate compared to free LDL Electrophoresis showed that after binding of LPS LDL acquired a negative charge These data suggest that the formation of LDLLPS complexes is accompanied by modification of LDL due to which they acquire atherogenic properties

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