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Title of Journal: Bull Exp Biol Med

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Abbravation: Bulletin of Experimental Biology and Medicine

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Springer US

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DOI

10.1007/s40265-016-0683-z

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ISSN

1573-8221

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Role of Heat Shock Protein 27 in Regulation of Glu

Authors: N V Ryazantseva E A Stepovaya O L Nosareva E V Konovalova D S Orlov A I Naumova S A Didenko O N Vesnina E V Shakhristova A P Zima V V Novitskii
Publish Date: 2015/01/09
Volume: 158, Issue: 3, Pages: 377-379
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Abstract

Reaction of the glutathione system of Jurkat tumor cells and blood lymphocytes was evaluated under conditions of culturing with 55ethyl2hydroxy4methoxyphenyl44methoxyphenyl isoxazole KRIBB3 a selective inhibitor of heat shock protein Hsp27 The results indicated the regulatory role of Hsp27 in the maintenance of the functional activities of glutathione reductase glutathione peroxidase and realization of apoptotic death of Jurkat cells and blood lymphocytes Inhibition of Hsp27 in Jurkat tumor cells led to imbalance of the glutathione system and increase of the share of annexinpositive cells


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