Authors: N V Ryazantseva E A Stepovaya O L Nosareva E V Konovalova D S Orlov A I Naumova S A Didenko O N Vesnina E V Shakhristova A P Zima V V Novitskii
Publish Date: 2015/01/09
Volume: 158, Issue: 3, Pages: 377-379
Abstract
Reaction of the glutathione system of Jurkat tumor cells and blood lymphocytes was evaluated under conditions of culturing with 55ethyl2hydroxy4methoxyphenyl44methoxyphenyl isoxazole KRIBB3 a selective inhibitor of heat shock protein Hsp27 The results indicated the regulatory role of Hsp27 in the maintenance of the functional activities of glutathione reductase glutathione peroxidase and realization of apoptotic death of Jurkat cells and blood lymphocytes Inhibition of Hsp27 in Jurkat tumor cells led to imbalance of the glutathione system and increase of the share of annexinpositive cells
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