Authors: V A Shkurupiy L B Kim I K Nikonova O V Potapova L A Cherdantseva T V Sharkova
Publish Date: 2013/01/16
Volume: 154, Issue: 3, Pages: 299-302
Abstract
In generalized BCG granulomatosis fibrosis starts early on day 3 and not only around the granulomas but also in the organs The severity of organ fibrosis is apparently determined by the concentration of granulomas in particular their macrophages inducing proliferation of fibroblasts in organs and granulomas as well as activation of fibrogenesis On day 30 after infection the degree of fibrosis in the lungs was by 6 times higher than in the liver The increase in hydroxyproline concentration in organs in early period of infection was determined by acute stress while on day 30 it resulted from its enhanced synthesis by granuloma fibroblasts and resident fibroblasts in organs
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