Authors: D M Gorbatova S A Litvinova A D Durnev S B Seredenin
Publish Date: 2015/03/17
Volume: 158, Issue: 5, Pages: 664-669
Abstract
Female outbred albino rats were daily subjected to forced inhalations of peat smoke 4 cores packed with a mixture of peat 70 and wood pulp 30 046 g pH at least 55 core burning time 6 min total exposure 44 min per se and in combination with oral afobazole anxiolytic in doses of 1 and 10 mg/kg on days 1–20 of pregnancy Some groups of females received oral afobazole 200 mg/kg after delivery due to which their newborn rats received the drug in doses of 1–10 mg/kg with maternal milk on days 1–20 of life Exposure to peat smoke inhibited body weight gain in the progeny on days 5–60 of life Afobazole treatment during the pre and postnatal periods prevented this effect Open field testing showed that exposure to peat smoke prolonged the motor activity in the progeny and impaired the loss of orientation and exploratory behavior during repeated testing Oral afobazole 1 and 10 mg/kg during the prenatal and/or postnatal period with maternal milk prevented the effects of peat smoke
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