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Title of Journal: Bull Exp Biol Med

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Abbravation: Bulletin of Experimental Biology and Medicine

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Publisher

Springer US

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DOI

10.1002/chin.199235258

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ISSN

1573-8221

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Mechanisms of the AntiInfl ammatory and Antifi br

Authors: E G Skurikhin E S Khmelevskaya O V Pershina T V Andreeva L A Ermolaeva V A Krupin N N Ermakova A M Reztsova I E Stepanova A M Dygai
Publish Date: 2012/10/18
Volume: 153, Issue: 5, Pages: 638-643
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Abstract

The effect of a course treatment with a sympatholytic reserpine on the infl ammatory response and connective tissue proliferation in the lungs of C57Bl/6 mice was studied on the model of toxic pulmonary fi brosis induced by intratracheal administration of bleomycin This sympatholytic reduced infi ltration of the alveolar interstitium and alveolar ducts with infl ammatory cells lymphocytes macrophages neutrophils and plasma cells and prevented connective tissue proliferation in the lungs The antiinfl ammatory effect of reserpine was associated with a decrease in activity of bone marrow granulocyteerythroidmacrophagemegakaryocyte and granulocyte precursors proliferation and mobilization The antifi brotic effect of reserpine was due to a decrease in the number of committed precursors for mesenchymopoiesis

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