Authors: A V Stepanov A S Rybinets M A Dronina S M Deev
Publish Date: 2016/06/06
Volume: 161, Issue: 1, Pages: 72-74
Abstract
Chimeric gp130 receptors were produced to study the role of three fibronectin type IIIlike domains in activation of gp130 receptor machinery The ligandinduced dimerization of gp130 was sufficient to trigger STAT3 signaling pathway These findings can be used as the basis in designing novel therapeutic gp130 inhibitors
Keywords: