Authors: E L Lushnikova L M Nepomnyashchikh V I Pichigin M G Klinnikova R D Nepomnyashchikh D S Sergeevichev
Publish Date: 2013/12/13
Volume: 156, Issue: 2, Pages: 271-275
Abstract
The expression of mRNA of matricellular proteins osteopontin and lumican apolipoproteins E and AIV and microsomal triglyceride transfer protein and the intensity of fibroplastic processes were studied in the myocardium of rats during experimental chronic hypercholesterolemia We have found that the development of chronic hypercholesterolemia was followed by an increase in volume density of interstitial connective tissue in the myocardium reflecting the activation of fibroplastic processes A slight positive correlation was observed between the connective tissue density in the myocardium and expression of osteopontin mRNA r = 0408 and lumican mRNA r = 0470 Myocardium remodeling during hypercholesterolemia is realized against the background of increased expression of apolipoproteins E and AIV mRNA and microsomal triglyceride transfer protein mRNA involved in transport and metabolism of lipoproteins in several tissues and probably play a pivotal role in the regulation of lipoprotein transport and metabolism in the myocardium We concluded that the increase in the expression of apolipoproteins E and AIV and microsomal triglyceride transfer protein play adaptive and compensatory role and is related to the increase in lipoprotein utilization by macrophages
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