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Title of Journal: Bull Exp Biol Med

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Abbravation: Bulletin of Experimental Biology and Medicine

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Springer US

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DOI

10.1016/0022-510x(85)90142-x

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ISSN

1573-8221

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Accumulation of Eicosapentaenoic Acid in Membranes

Authors: N M Shilina O N Komarova F A Medvedev M I Dubrovskaya I Ya Kon’
Publish Date: 2010/09/29
Volume: 149, Issue: 5, Pages: 583-586
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Abstract

Children patients with alterativeexudative gastrointestinal diseases and allergic inflammation bronchial asthma exhibited similar changes in fatty acide composition of erythrocyte and leukocyte membranes They included accumulation of considerable amounts of eicosapentaenoic acid and decrease in the content of docosahexaenoic acid longchain derivative of eicosapentaenoic acid The accumulation of eicosapentaenoic acid and decrease in the content of docosahexaenoic acid in cell membranes probably play a role in the pathogenesis of chronic inflammatory diseases It is related to a possible decrease in the formation of antiinflammatory eicosanoids series5 leukotrienes and protective compounds resolvins and protectins from fatty acids and changes in the physicochemical properties of cell membranes

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