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Title of Journal: Bull Exp Biol Med

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Abbravation: Bulletin of Experimental Biology and Medicine

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Springer US

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DOI

10.1016/0022-1902(58)80144-x

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ISSN

1573-8221

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Role of TissueSpecific Stem and Progenitor Cells

Authors: E G Skurikhin A V Pakhomova N N Ermakova O V Pershina V A Krupin E S Pan A I Kudryashova L A Ermolaeva A M Dygai
Publish Date: 2016/11/23
Volume: 162, Issue: 1, Pages: 146-152
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Abstract

Using the model of hypogonadism in C57Bl/6 male mice we showed that injection of streptozotocin to newborn animals and highfat diet induced serum IFNγ and IL17 elevation glucose metabolism disturbances insulin resistance destructive changes of the Langerhans islets deficit of PDX1+β cells while the number of oligopotent β cell precursors CD45—TER119—CD133+CD49flow increased Diabetes played the role of an inducer of testicular tissue inflammation panhemopoietic cell infiltration increase of IL2 IL17 and IL23 content and reproductive system disturbances in mice decrease in free testosterone concentration suppression of spermatogenesis and infertility The development of hypogonadism was paralleled by an increase in the count of spermatogonial stem cells CD117+CD29+CD90+ multipotent mesenchymal stromal cells CD45—CD31—CD90+CD106+ hemangiogenesis precursors CD45—CD117+Flk1+ and epithelial cells CD45—CD31—CD49f+CD326+

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