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Title of Journal: Bull Exp Biol Med

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Abbravation: Bulletin of Experimental Biology and Medicine

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Springer US

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DOI

10.1016/j.ajog.2014.10.482

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ISSN

1573-8221

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Regional Features of the Expression of Genes Invol

Authors: V V Kolobov Z I Storozheva M A Gruden V V Sherstnev
Publish Date: 2012/10/20
Volume: 153, Issue: 5, Pages: 746-749
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Abstract

The expression of mRNA of genes involved in neurogenesis and apoptosis Apaf1 Ascl1 Bax Bcl2 Casp3 Casp8 Casp9 Dffb Myh10 Naip2 Napa Notch2 Numb Pura S100a6 Tnf in the prefrontal cortex hippocampus and cerebellum was studied in adult rats The content of mRNA of these genes except Apaf1 was severalfold higher in the cerebellum than in the hippocampus and brain cortex In the hippocampus the expression of Apaf1 was significantly lower than in the prefrontal cortex while the expression of Ascl1 Pura S100b and Tnf was higher Regional differences in the direction strength and numbers of significant correlations between the expression of the studied genes were detected Documented differences in gene expression were regarded as validation of the structural and functional cooperation of neurogenesis and apoptosis at the molecular genetic level

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