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Title of Journal: Bull Exp Biol Med

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Abbravation: Bulletin of Experimental Biology and Medicine

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Springer US

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DOI

10.1007/bf00114662

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ISSN

1573-8221

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Phenotypic Plasticity of Retinal Pigment Epithelia

Authors: L A Milyushina A V Kuznetsova E N Grigoryan M A Aleksandrova
Publish Date: 2011/08/17
Volume: 151, Issue: 4, Pages: 506-
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Abstract

Phenotypic plasticity of retinal pigment epithelial cells from adult human eye was studied by immunohistochemical methods under different culturing conditions It was found that retinal pigment epithelium in adult human eye is a heterogeneous population of cells demonstrating different behavior in vitro Some cells retain epithelial morphology for a long time in culture while others are rapidly transformed into fibroblastlike cells and synthesize proteins typical of proneural neural glial and photoreceptor cells However irrespective of initial morphological features differentiation of retinal pigment cells can be modulated by varying culturing conditions

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